Introducing Nurf

Say Hello to Nurf :)

"The Drosophila nucleosome remodeling factor (NURF) is a protein complex of four distinct subunits that assists transcription factor-mediated chromatin remodeling. One NURF subunit, ISWI, is related to the transcriptional regulators Drosophila brahma and yeast SWI2/SNF2. We have determined peptide sequences and isolated cDNA clones for a second NURF component (the 55-kDa subunit). Immunological studies show that p55 is an integral subunit of NURF and is generally associated with polytene chromosomes. The predicted sequence of p55 reveals a WD repeat protein that is identical with the 55-kDa subunit of the Drosophila chromatin assembly factor (CAF-1). Given that WD repeat proteins related to p55 are associated with histone deacetylase and histone acetyltransferase, our findings suggest that p55 and its homologs may function as a common platform for the assembly of protein complexes involved in chromatin metabolism."

Taken from the abstract of Drosophila NURF-55, a WD repeat protein involved in histonemetabolism Marian A. Martínez-Balbás, Toshio Tsukiyama, David Gdula, and Carl WuProc Natl Acad Sci U S A. 1998 January 6; 95(1): 132–137.

Just kidding lah, this is the Nurf i'm talking about:

Woot! I got "killed" 4 times this morning! HEHEHE